I been running ozone on my 6ft tank since day 1 . My skimate from my aquamedic 5000baby is also very litter and dry and the only time my skimmer go crazy is when i have a death fish in my tank. If we dose it direct into out skimmer the reaction only take place in the skimmer so by the time the water leave the skimmer it should be free of ozone . So far i been using it for more than 4 months if i not wrong and it doing well for my tank . And i just upgraded from a 50mg to 200mg cos i find 50mg under dose for my tank . I also add a coralife 6x to my tank and i find that help alot during my very bad ICH out break.